Shandong Sino Pharmaceutical Technology Co., Ltd.

• Mechanism:
  Potent loop diuretic that inhibits the Na/K/2Cl cotransporter in the ascending limb of the loop of Henle, resulting in profound diuresis.

• Therapeutic Effects:

  • Rapid reduction of fluid overload

  • Decreased systemic/pulmonary congestion

  • Blood pressure control

• Edema (cardiac, hepatic, or renal origin)

• Hypertension (adjunctive therapy)

• Acute pulmonary edema (IV form)

• Hypercalcemia (adjunct treatment)

Adults:

• Oral (tablets):

  • Initial: 20-80 mg as single morning dose

  • Maintenance: 20-120 mg/day (max 600 mg/day in divided doses)

• IV/IM:

  • Acute edema: 20-40 mg slow IV push (may repeat in 2 hrs)

  • Continuous infusion: 10-40 mg/hr (for refractory cases)

Pediatrics:

• Oral: 1-2 mg/kg/dose (max 6 mg/kg/day)

• IV: 0.5-1 mg/kg/dose (max 6 mg/kg/day)

Special Populations:

• Renal impairment: Reduce frequency (not dose)

• Elderly: Start with lower doses

• Tablets:

  • Store below 25°C (77°F)

  • Protect from light and moisture

  • Keep container tightly closed

• Injection:

  • Unopened vials: Room temperature (15-30°C) or refrigerated (2-8°C)

  • Do not freeze

  • Use immediately after opening
    
    

• Contraindications:

  • Anuria

  • Hepatic coma

  • Severe electrolyte depletion

  • Hypersensitivity to sulfonamides

• Monitoring Parameters:

  • Serum electrolytes (K,Na, Mg)

  • Renal function

  • Blood pressure

  • Hearing (with high doses)

• Drug Interactions:

  • Aminoglycosides (↑ ototoxicity risk)

  • Digoxin (↑ toxicity with hypokalemia)

  • NSAIDs (↓ diuretic effect)

  • Lithium (↑ lithium levels)

• Common: Dehydration, hypokalemia, hypotension

• Serious: Ototoxicity (with rapid IV), pancreatitis, Stevens-Johnson syndrome

Currently, we are sourcing the distributors or agents all around the world.
 
Please do not hesitate to contact us immediately if you are interested in this product.
 
Looking forward to strong cooperation with you in the near future!


Brief Introduction to Our Company:
Shandong Sino Pharmaceutical Technology Co., Ltd. (S.S.P.T.)  is a different kind of pharmaceuticals (both finished medicine products and raw materials), health products, cosmetics and medical supplies company for human needs, focusing on global markets, especially the developing world. Working with the highest levels of government and local distributors alike, we aim to not only expand our business scale and scope but also have a special interest in serving the needs of the end consumer that requires our products the most. To this end, we have a presence in 5 continents with an expanding product range to meet the demand of our main markets.
 
Moreover, our manufacturing facilities follow strict GMP rules and regulations. We have intergraded all GMP guidelines into internal procedures improving the degree to which results are consistently exceeding expectations. As one of the best pharmaceutical companies in China, we take our ethical obligation to improving access to high quality and affordable WHO essential drugs seriously. This is the ethical basis our company was founded on.