Shandong Sino Pharmaceutical Technology Co., Ltd.

We are supplying all of our  foreign customers with Customized Pharmaceutical Formulations or Dosage Forms.

You can tell us any pharmaceutical product, no matter what it is that you want. And then we will give you a detailed solution as per your requirement.  

①. Core features

1. Biocompatibility: Both PLLA and PEG have good biocompatibility. This copolymer has overall low toxicity and low immunogenicity. After implantation in the human body, it will not cause obvious inflammation or rejection reactions. Moreover, PEG can dissolve in human tissue fluid, and low-molecular-weight PEG can also be excreted from the body through the renal filtration membrane.

2. Biodegradability: The PLLA chain segments can be gradually degraded into small molecule substances in the body and excreted through metabolism. The PEG chain segments do not accumulate harmful substances in the body, and the entire degradation process has no adverse effects on the body, meeting the environmental protection and safety requirements of biomedical materials.

3. Adjustable hydrophilicity and hydrophobicity: It belongs to amphiphilic materials, with PEG being the hydrophilic section and PLLA being the hydrophobic section. By adjusting the ratio of the two and the length of the chain segments, the hydrophilicity and hydrophobicity of the material can be flexibly regulated, thereby changing its degradation rate and drug release behavior.

4. Controllable mechanical properties :PLLA provides basic mechanical strength for materials, meeting the requirements of load-bearing scenarios; PEG enhances the softness and toughness of materials. Moreover, its mechanical properties can also be regulated by changing the molecular configuration. For instance, compared with the linear structure, the star-shaped structure has better flexibility and toughness.


②. Main application fields


1. Drug delivery system: With its amphiphilic structure, it can self-assemble into micelles or nanoparticles. The hydrophobic PLLA core can encapsulate hydrophobic anti-tumor drugs, anti-inflammatory drugs, etc., and the hydrophilic PEG shell can prolong the time of drugs in the bloodstream and reduce the probability of being cleared by the immune system. At the same time, by adjusting the molecular weight and the proportion of chain segments, the release rate of the drug can be precisely controlled, thereby enhancing the stability and effectiveness of the drug's action.

2. Tissue Engineering: Fiber scaffolds can be prepared through electrospinning and other techniques to simulate extracellular matrix, providing support for the growth and adhesion of cells in skin, bone and other tissues, and facilitating tissue repair and regeneration. For instance, in skin tissue engineering, its scaffold can promote the migration of skin cells and accelerate wound healing. When used for bone tissue-related scaffolds, it can take into account both support and degradability, and is suitable for the bone regeneration cycle.

3. Medical devices and regenerative medical aesthetics: On the one hand, they can be used to manufacture biodegradable sutures, bone screws, etc. Their mechanical strength can meet the surgical requirements, and they can degrade by themselves after surgery, avoiding the need for secondary surgery to remove them. On the other hand, it can be used as a surface coating for cardiovascular interventional devices, reducing the adsorption of blood proteins and platelets and lowering the risk of thrombosis. In the field of medical aesthetics, PLLA materials modified by PEG can be used as dermal fillers, which can not only achieve filling and shaping but also stimulate collagen regeneration and improve skin quality.