Shandong Sino Pharmaceutical Technology Co., Ltd.

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1.Mechanism of Action

FOXO4-DRI is a synthetic peptide designed to disrupt the interaction between the FOXO4 transcription factor and the p53 protein. This interaction is crucial for the survival of senescent cells, which are cells that have ceased to divide but remain metabolically active and release pro-inflammatory factors. By interfering with this interaction, FOXO4-DRI selectively induces apoptosis (programmed cell death) in senescent cells, thereby reducing inflammation and improving tissue function. This mechanism is particularly effective in clearing out dysfunctional cells that contribute to aging and age-related diseases.

2.Application Prospects

FOXO4-DRI holds significant potential in several therapeutic areas:

1. Anti-Aging Therapies: By selectively eliminating senescent cells, FOXO4-DRI can reduce the cellular burden associated with aging, potentially extending healthspan and improving overall tissue function.
2. Age-Related Diseases: FOXO4-DRI is being studied for its potential to mitigate conditions such as osteoarthritis, atherosclerosis, and neurodegenerative diseases by reducing the Senescence-Associated Secretory Phenotype (SASP) and improving cellular microenvironments.
3. Cancer Treatment: In oncology, FOXO4-DRI may target senescent cells within the tumor microenvironment, potentially impeding cancer progression and metastasis.
4. Regenerative Medicine: By clearing out senescent cells, FOXO4-DRI can enhance tissue repair and regeneration, improving the efficacy of stem cell therapies.

3. Usage Instructions

FOXO4-DRI is typically administered via subcutaneous injection. The recommended dosage and frequency depend on the specific therapeutic goal and individual needs. For general anti-aging and tissue health, a common protocol involves 100-400 mcg per injection, administered every other day for a total of three injections. However, it is crucial to note that FOXO4-DRI is primarily in the research phase, and its use should be guided by a healthcare professional.

4. Precautions and Considerations

1. Medical Supervision: FOXO4-DRI should be used under the guidance of a healthcare professional to ensure appropriate dosage and administration.
2. Potential Side Effects: While FOXO4-DRI has shown minimal short-term side effects in preclinical studies, its long-term effects and potential side effects in humans are not fully understood. More research is needed to establish its safety profile.
3. Regulatory Status: FOXO4-DRI is not FDA-approved and is still in the research stage. Its use outside of clinical trials or research settings may be subject to legal and regulatory restrictions.

5.Storage

FOXO4-DRI should be stored in a cool, dry place, preferably between 2°C and 8°C (36°F and 46°F) to maintain its stability and bioactivity. It is typically provided as a freeze-dried powder and requires reconstitution with sterile water or a suitable solvent before use.

SummaryFOXO4-DRI is a groundbreaking senolytic peptide with the potential to revolutionize the treatment of aging and age-related diseases. Its targeted mechanism of action offers a novel approach to selectively eliminate senescent cells, thereby improving tissue function and reducing inflammation. While promising, its use is still in the experimental phase, and further research is needed to fully understand its therapeutic potential and safety profile.