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Mechanism of Action
Reta*tru*tide is a triple receptor agonist targeting the glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent polypeptide receptor (GIPR), and glucagon receptor (GCGR). It works through the following mechanisms:
- GLP-1R Activation: Reta*tru*tide stimulates secretion and inhibits glucagon release, which helps lower blood glucose levels. It also delays gastric emptying, reducing appetite.
- GIPR Activation: This action enhances secretion and contributes to further blood glucose reduction.
- GCGR Activation: By promoting fat breakdown and energy metabolism, it aids in weight reduction.
Effect
- Weight Loss: Reta*tru*tide has shown significant weight loss effects in clinical trials, making it suitable for obese patients or those with metabolic syndrome.
- Blood Glucose Control: It effectively lowers blood glucose levels and improves sensitivity, making it beneficial for type 2 diabetes patients.
- Cardiovascular Health: Early data suggest potential cardiovascular benefits, similar to other GLP-1 class drugs.
| Product Name | Sinoglp-1 |
| Active Ingredient | Reta*tru*tide |
| Dosage Form | Injection |
| Strength | 5mg per vial |
| Diluent | 10ml sterile water for injection |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) |
| Packaging | 1 vial (Reta*tru*tide 5mg) + 1 injection vial (10ml sterile water for injection) |
| Manufacturer | Sinopharmatech Co., Ltd. |
Dosage and Administration
- Route of Administration: Reta*tru*tide is currently administered via subcutaneous injection, typically once a week.
- Dosage: Clinical trials have explored doses of 4mg, 8mg, and 12mg. The specific dosage should be determined by a healthcare provider based on individual patient needs.
Contraindications
- Hypersensitivity: Patients with a known hypersensitivity to Reta*tru*tide or any of its excipients should not use this medication.
- Medical Conditions: It may not be suitable for patients with certain medical conditions. A thorough medical evaluation is necessary before starting treatment.
Transportation and Storage
- Transportation: Reta*tru*tide should be transported under refrigerated conditions to maintain its stability.
- Storage: It should be stored at -20ºC, with a shelf life of 2 years. Once dissolved in a solvent, it should be used within one month at -20ºC.
